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Natural Product Research
Formerly Natural Product Letters
Volume 38, 2024 - Issue 5
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Research Articles

Aspidiatas C and D, two new spirostanol saponins from Aspidistra triradiata and their cytotoxic activities

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Pages 829-837 | Received 09 Jan 2023, Accepted 08 Apr 2023, Published online: 26 Apr 2023
 

Abstract

Aspidiatas C and D (1 and 2), two new spirostanol saponins, were isolated along with two known compounds, (25 R*)-spirost-5-en-3β-yl α-L-rhamnopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside (3), (25 R*)-spirost-5-en-3β-yl α-L-rhamnopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranoside (4) from the whole plant of Aspidistra triradiata collected in Vietnam. The chemical structures were determined by HRESIMS, 1D- and 2D-NMR analysis, and comparison with published data. Compound 3 exhibited potent cytotoxicity against MCF7, HepG2, SK-LU-1, and HT-29 human cancer cell lines with IC50 values ranging from 0.19 to 0.65 µM. Compounds 1, 2, and 4 displayed moderate cytotoxic effects with IC50 values ranging from 12.32 to 82.27 µM. Compounds 14 were isolated from the genus Aspidistra for the first time.

GRAPHICAL ABSTRACT

Acknowledgments

We are grateful to Mr. Luong Vu Dang (Institute of Chemistry, VAST, Hanoi, Vietnam) for recording the NMR spectra.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by Hue University under Grant (ID No. DHH2022-04-160). Le Thi Bich Hien was funded by the Master, PhD Scholarship Programme of Vingroup Innovation Foundation (VINIF), code VINIF.2022.TS039.

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