A computer-aided insight into the identification of significant therapeutic flavone as a promising agent for sarcopenic obesity

Abstract

Polyphenols, the important secondary metabolites, consist of multiple phytochemicals and show numerous physiological effects. Flavones play a significant role in various chronic disorders such as diabetes.. In this study, all the flavones were encountered, and it was further filtered based on their drug-likeness properties and pharmacokinetic parameters. Existing literature confirms that flavone-based compounds are suitable as the drug of choice in sarcopenic obesity. A molecular docking study was performed toward the myostatin inhibition profile of the flavones using PDB:3HH2 as a target site. This computer-aided drug design helps select lead molecules in novel drug discovery.

Graphical Abstract

Keywords:

• Flavones
• sarcopenia
• obesity
• docking
• in silico

Acknowledgement

We would like to thank SRMIST for providing technical-oriented sources.

Author contributions

Sarvesh Sabarathinam: designed the research and carried out the experiment and Sanjana Satheesh and Arun Raja: analyzed the data. All authors read and approved the final manuscript.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.