Vibrational dynamics of inclusion complexes by Raman scattering: an experimental and numerical study

Abstract

Raman spectroscopy has been applied to the study of interactions involved in the formation of inclusion complexes between cyclodextrins and indomethacin. Raman spectra of free molecules and of their inclusion complexes have been recorded in the energy ranges 10–50 and 100–3500 cm⁻¹, and significant energy shifts, intensity variations and broadening have been observed due to complexation. The experimental data have been interpreted by comparison with the results of numerical simulation.

Acknowledgements

We would like to thank G. Mariotto for making the micro-Raman apparatus available, and Mr. A. Sterni for technical assistance in the MS analysis.