Effects of a short length alcohol on the dimyristoylphosphatidylcholine system

Abstract

We have investigated the dimyristoylphosphatidylcholine system with a high concentration of butanol (two molecules per phospholipid) via X-ray diffraction, differential scanning calorimetry and density measurements. A lowering of the main transition temperature for the membrane/alcohol system has been observed. The phospholipid bilayer/alcohol system is characterised by a higher density value than the pure membrane, as determined by volumetric measurements. Analysis of diffraction patterns has shown the existence of a more packed structure due to the presence of alcohol. The area of polar head has also been estimated.

Keywords:

• volumetric measurements
• membrane
• butanol
• biological materials
• biomolecules
• calorimetry
• DSC
• X-ray diffraction