Abstract
In the present study we have synthesized esters of acyclovir (2–4) with cinnamic acids (p-coumaric, ferulic, and sinapic acids) and evaluated them for their antiviral and antioxidant potential. The antiviral activity of the newly synthesized compounds has been tested against human herpes virus 1 (HSV-1) in vitro. The results indicate that none of the synthesized compounds inhibits the tested virus strain. The antioxidant properties have been studied using 2,2-diphenyl-1-picrylhydrazyl (DPPH)* test.
Acknowledgments
For the support of this work, the authors are grateful to the National Science Fund, Bulgaria (Contracts VUL-304/07), DAAD project 03/2007, and South-West University “Neofit Rilski,” Blagoevgrad, Bulgaria (SRP-C2/2010).