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Abstract
The mitochondrial enzyme thymidine kinase 2 (TK2) phosphorylates deoxythymidine (dT) and deoxycytidine (dC) to form dTMP and dCMP, which in cells rapidly become the negative-feedback end-products dTTP and dCTP. TK2 kinetic activity exhibits Hill coefficients of ∼0.5 (apparent negative cooperativity) for dT and ∼1 for dC. We present a mathematical model of TK2 activity that is applicable if TK2 exists as two monomer forms in equilibrium.
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Acknowledgments
The authors thank the reviewers for their suggestions. T. R. was supported by the NCI (K25CA104791). B. M.-P. was supported by the Danish Research Council and the Novo Nordic Research Council. S. E. and L. W. were supported by the Swedish Research Council and the Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning.
