New Thymine-Based Derivative of Nitrogen Mustards

Abstract

This work deals with the synthesis of a new nitrogen mustard derivative based on thymine. To introduce the bis(2-chloroethyl)amine group to position 4 of the pyrimidine base, many strategies were explored and the desired compound was finally obtained, thanks to a synthetic pathway in five steps.

Keywords:

• Base modification
• nitrogen mustards
• thymine