Synthesis and Characterization of Some New N-Glycosides of Pyridine-2,6-bis-Carboxamides Derivatives

Mohammed E. AzabChemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt

Nagy M. KhalifaPharmaceutical Chemistry Department, Drug Exploration & Development Chair, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia;Therapeutical Chemistry Department, National Research Centre, Dokki, Cairo, Egypt

Ashraf A. SediekChemical Industries Division, National Research Centre, Dokki, Cairo, Egypt;Chemistry Department, Faculty of Sciences and Arts, Al-Kamil Branch, University of Jeddah, Jeddah, Saudi Arabia

Nermein M. SabryChemical Industries Division, National Research Centre, Dokki, Cairo, Egypt

Mohamed M. Al-OmarPharmaceutical Chemistry Department, Drug Exploration & Development Chair, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

Abd El-Galil E. AmrPharmaceutical Chemistry Department, Drug Exploration & Development Chair, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia;Chemical Industries Division, National Research Centre, Dokki, Cairo, EgyptCorrespondence[email protected]

ABSTRACT

A series of novel pyridine-bridged 2,6-bis-carboxamide N-β-glycosides and Schiff's bases has been prepared starting from 2,6-bis-carboxamide pyridine hydrazide, which on treatment with appropriate monosaccharides, aromatic or heterocyclic aldehydes, and indoline-2,3-dione derivatives afforded the corresponding sugar hydrazones and pyridine-bridged 2,6-bis-carboxamide Schiff's bases.

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Funding

The project was financially supported by Vice Deanship of Research Chairs, King Saud University, Riyadh, Saudi Arabia.

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Synthesis and Characterization of Some New N-Glycosides of Pyridine-2,6-bis-Carboxamides Derivatives

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Synthesis and Characterization of Some New N-Glycosides of Pyridine-2,6-bis-Carboxamides Derivatives

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