Ecofriendly microwave assisted synthesis of some new pyridine glycosides

Abstract

An efficient, mild and rapid procedure was employed to prepare a novel series of pyridine glycosides. The protocol allows the reaction of 2-pyridone with 1,2,3,4,6-penta-O-acetyl-α-D-glucopyranose under solvent-free microwave-assisted synthesis using different solid supports. Silica gel has been found to be an efficient and environmentally friendly promoter. Structures of the new products were confirmed based on their elemental analyses and spectral data (LC-MS/MS, IR, UV, 1D- and 2D-NMR).

Keywords:

• Microwaves synthesis
• pyridine nucleosides
• 2D-NMR and solid support

Acknowledgement

Support of this research from Taif University, Kingdom of Saudi Arabia, under a Research Project Grant Award 1-438-5953 is gratefully acknowledged.