Association between the IL-1A, IL-1B and IL-1R polymorphisms and lymphoma

Abstract

We investigate the impact of IL-1A, IL-1B and IL-1R1 polymorphism on lymphoma. This study consisted of 155 Non-Hodgkin’s lymphoma (NHL) patients 55 Hodgkin’s lymphoma (HL) patients and 150 healthy individuals. PCR-RFLP method and ARMS PCR were used for genotyping of IL-1A rs3783553, IL-1B rs3917356, rs16944, IL-1R1 rs10490571 and IL-1A rs3783550 polymorphism. The results showed that the CC genotype of rs3783550 as well Ins/del of rs3783553 increased the risk of NHL. In contrast the AG genotype of rs3917356 and AG also AG + AA genotype of rs10490571 decreased the risk of NHL. The result revealed that the CC genotype of rs3783550 and AG genotype of rs3917356 increased risk of HL.

Keywords:

• Interleukin-1
• polymorphism
• lymphoma

Acknowledgments

The authors thank to the patients and healthy subjects who willingly participated in the study.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was funded by a research grant (#8999) from Zahedan University of Medical Sciences.