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Abstract
Novel modified cytosine analogs bearing phosphodiester/thiophosphodiester functionality were synthesized. The interactions between different metal ions and modified cytosine-cytosine base-pairs in DNA duplexes were investigated by UV-melting experiments. The thiophosphodiester modification binds to the Ag(I) ions strongly compared to the phosphodiester counterpart as examined in ESI-MS spectra as well.
Acknowledgement
ATMZA also thanks the Japan Society for the Promotion of Science (JSPS) for granting him a postdoctoral fellowship.
Additional information
Funding
This work was partly supported by a Grant-in-Aid for Scientific Research (B) (16350090) and the “Scientific Frontier” Project (2006-2011) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan, and by the Mitsubishi Foundation.