Synthesis of 2′-Amino-LNA Purine Nucleosides

Jacob Ravn Santaris Pharma A/S, H⊘rsholm, Denmark

Christoph Rosenbohm Santaris Pharma A/S, H⊘rsholm, Denmark

Signe M. Christensen Santaris Pharma A/S, H⊘rsholm, Denmark; Novo Nordisk A/S, DK-2760, Mål⊘v, Denmark

Troels Koch Santaris Pharma A/S, H⊘rsholm, Denmark

Abstract

The first reported synthesis of 2′-amino-LNA purine nucleosides via a transnucleosidation is accomplished enabling the preparation of oligonucleotides incorporating 2′-amino-LNA with all four natural bases.

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Synthesis of 2′-Amino-LNA Purine Nucleosides

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Synthesis of 2′-Amino-LNA Purine Nucleosides

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