Abstract
In order to study structure-activity relationships among the derivatives and congeners of 5′,9-anhydro-3-(β-D-ribofuranosyl)xanthine for anti-hepatitis C virus activity, a series of 5′,9-anhydro-purine-isonucleosides with a substituent (s) at 6- or/and 8-position of the purine moiety were synthesized, and their anti-hepatitis C virus activity and cytotoxicity were evaluated and discussed.
This work was supported in parts by the NIH grants 1R43 AI-52868 (biology) and 1R43AI-056720 (chemistry).
Notes
1EC90(μM) is a concentration that reduces 90% of the viral RNA in the replicon system cell.
2CC50 (μM) is a concentration that reduces 50% of cellular mRNA in the replicon system cell.
3IC50 (μM) is a concentration that reduces 50% of cellular growth.
4Not determined.