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A versatile and conformationally preorganized universal linker molecule is reported here for efficient synthesis of phosphorothioate oligonucleotides. With respect to nucleoside loaded support, comparable yield and quality based on ion-pair LC-MS are obtained for both deoxy and 2′-O-methoxyethyl modified phosphorothioate oligonucleotides. No 3′-phosphate or phosphorothioate monoester or any modification of universal molecule still attached to oligonucleotide was observed.
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