Abstract
3 ′-S-Phosphorothiolate linkages incorporated into an oligodeoxynucleotide have been shown to stabilise duplex formation with a complementary RNA strand, but destabilise a duplex formed with a complementary DNA strand. The four-stranded i-motif structure is also stabilised this modification.
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Notes
a 50 mM sodium citrate buffer, pH 4.6, 5 μ M strand concentration.