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Abstract
This work studies the binding properties of distamycin and its carbamoyl analog, containing four pyrrole units, with the [d(TGGGGT)] 4 quadruplex by means of isothermal titration calorimetry (ITC). Analysis of the ITC data reveals that drug/quadruplex binding stoichiometry is 1:1 for both interactions and that distamycin analog gives approximately a 10-fold increase in the quadruplex affinity.
Acknowledgments
This work was supported by a PRIN-MURST from the Italian “Ministero dell'Università e della Ricerca Scientifica e Tecnologica” (Rome).
