Some Novel Adenosine Mimics: Synthesis and Anticancer Potential against Cervical Cancer caused by Human Papilloma Virus

Sarika Sinha Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad, India

Richa Srivastava Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad, India

Bhupesh Prusty Institute of Cytology and Preventive Oncology (ICMR), Noida, India

B. C. Das Institute of Cytology and Preventive Oncology (ICMR), Noida, India

Ramendra K. Singh Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad, India

Abstract

Two novel adenosine analogs, viz. 9-(1′-β-D-arabinofuranosyl)-6-nitro-1,3-dideazapurine or Ara-NDDP (1) and 9-(5′-deoxy-5′-S-(propionic acid) (1′-β-D-ribofuranosyl) adenine or SAH analog (2), indigenously synthesized, have been found to be potential anticancer agents against cervical cancer caused by human papilloma virus.

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Acknowledgments

This work was supported by grants from the University Grants Commission and Department of Science and Technology, New Delhi, Government of India.

Sarika Sinha is currently with the Department of Microbiology & Cell Biology, IISc, Bangalore, India

Richa Srivastava is currently with the Molecular Biophysics Unit, Indian Institute of Science, Bangalore - 560 012, India

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Some Novel Adenosine Mimics: Synthesis and Anticancer Potential against Cervical Cancer caused by Human Papilloma Virus

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Some Novel Adenosine Mimics: Synthesis and Anticancer Potential against Cervical Cancer caused by Human Papilloma Virus

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