Synthesis of Anthraquinone Oligonucleotides for Triplex Stabilization

Zhengyun Zhao School of Chemistry, University of Southampton, Highfield, Southampton, United Kingdom

Guomei Peng School of Chemistry, University of Southampton, Highfield, Southampton, United Kingdom

Jan Michels Department of Chemistry, University of Hamburg, Hamburg, Germany

Keith R. Fox School of Biological Sciences, University of Southampton, Southampton, United Kingdom

Tom Brown School of Chemistry, University of Southampton, Highfield, Southampton, United Kingdom

Abstract

The synthesis of two anthraquinone phosphoramidites is described. In both cases the anthraquinone moiety is attached via a linker to the 5-position of a uracil base, allowing incorporation at any thymidine position in an oligonucleotide sequence. Anthraquinone-modified oligonucleotides have potential applications as triplex stabilizers and fluorescence quenchers.

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Acknowledgments

This research is funded by BBSRC. All oligonucleotide synthesis and purification was carried out by ATDBio Ltd., UK (www.atdbio.com).

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Synthesis of Anthraquinone Oligonucleotides for Triplex Stabilization

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Synthesis of Anthraquinone Oligonucleotides for Triplex Stabilization

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