Hairpin Mimics with Phenanthroline- and Bipyridine-Derived Linkers

Abstract

The synthesis and structural stabilities of modified oligonucleotide hairpins containing phenanthroline- and bipyridine-modified loops is reported. Phenanthroline (phen) and bipyridine (bipy) building blocks were synthesized, incorporated into DNA-oligonucleotides, and analyzed by thermal denaturation experiments. The so modified oligomers were found to form stable hairpin structures. Tm values were not affected by divalent transition metals.

Keywords:

• oligonucleotide hairpins
• phenanthroline
• bipyridine
• thermal denaturation

Notes

^a Values not determined.