Synthesis and Biophysical Characterization of G-Rich Oligonucleotides Conjugated with Sugar-Phosphate Tails

J. D'Onofrio Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli “Federico II,”, Napoli, Italy

E. Erra Dipartimento di Chimica, Universitá degli Studi di Napoli “Federico II,”, Napoli, Italy

G. Di Fabio Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli “Federico II,”, Napoli, Italy

A. Iadonisi Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli “Federico II,”, Napoli, Italy

L. Petraccone Dipartimento di Chimica, Universitá degli Studi di Napoli “Federico II,”, Napoli, Italy

L. De Napoli Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli “Federico II,”, Napoli, Italy

G. Barone Dipartimento di Chimica, Universitá degli Studi di Napoli “Federico II,”, Napoli, Italy

J. Balzarini Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium

C. Giancola Dipartimento di Chimica, Universitá degli Studi di Napoli “Federico II,”, Napoli, Italy

D. Montesarchio Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli “Federico II,”, Napoli, Italy

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Abstract

A number of 5′-and 3′-glycoconjugates of the oligonucleotide ⁵′d(TGGGAG)³′ have been synthesized, exploiting fully automated, online phosphoramidite-based solid phase strategy, as potential anti-HIV-1 agents. The thermodynamic stability of the resulting quadruplexes has been investigated by thermal denaturation studies, via a detailed CD Q1 analysis.

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Synthesis and Biophysical Characterization of G-Rich Oligonucleotides Conjugated with Sugar-Phosphate Tails

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Synthesis and Biophysical Characterization of G-Rich Oligonucleotides Conjugated with Sugar-Phosphate Tails

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