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Original Articles

Synthesis and Characterization of Tetra-End Linked Oligonucleotides Capable of Forming Monomolecular G-Quadruplexes

, , , , , & show all
Pages 1231-1236 | Published online: 05 Dec 2007
 

Abstract

The chemical synthesis of two new G-rich Tetra-End-Linked-oligodeoxyribonucleotides (TEL-ODNs) as well as 1H-NMR and CD spectra of the corresponding monomolecular quadruplexes (IVa and IVb) has been reported. The new TEL-ODNs, characterized by the presence of short branches in the linker moiety, could be very useful for the achievement of monomolecular quadruplexes with predetermined strand orientation.

This work is supported by Italian MURST (PRIN 2005). The authors are grateful to Centro di Servizi Interdipartimentale di Analisi Strumentale (CSIAS), for supplying the NMR facilities.

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