Abstract
The chemical synthesis of two new G-rich Tetra-End-Linked-oligodeoxyribonucleotides (TEL-ODNs) as well as 1H-NMR and CD spectra of the corresponding monomolecular quadruplexes (IVa and IVb) has been reported. The new TEL-ODNs, characterized by the presence of short branches in the linker moiety, could be very useful for the achievement of monomolecular quadruplexes with predetermined strand orientation.
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This work is supported by Italian MURST (PRIN 2005). The authors are grateful to Centro di Servizi Interdipartimentale di Analisi Strumentale (CSIAS), for supplying the NMR facilities.