Synthesis Study of 2′-O-(2-Methoxyethyl)-Purine Derivatives

Abstract

Alkylation of adenosine and 2-aminoadenosine was studied in dimethylsulfoxide with application of 1-methanesulfonyloxy-2-methoxyethane as an alkylating agent and t-BuOK, KOH and NaH as bases under mild heating. Using new reaction conditions, the improved synthesis of 2′-O-MOE-purine derivatives is described.

Keywords:

• Nucleosides
• purine
• methanesulfonyloxy-2-methoxyethane
• 2′-O-MOE der- ivatives

This work was supported from Belarus State Program of FOI “Physiological Active Compounds” (Grant 2.04).