Dual-Probe System Using Pyrenylmethyl-Modified Amino-Lna for Mismatch Detection

Tadashi Umemoto Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Odense, M, Denmark

Patrick J. Hrdlicka Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Odense, M, Denmark

B. Ravindra Babu Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Odense, M, Denmark

Jesper Wengel Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Odense, M, Denmark

Abstract

A dual-probe containing pyrenylmethyl amino-LNA has been developed for sensitive mismatch detection. While hybridization with complementary DNA/RNA results in very strong excimer signals, exposure to singly mismatched DNA/RNA targets results in significantly decreased excimer emission.

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Dual-Probe System Using Pyrenylmethyl-Modified Amino-Lna for Mismatch Detection

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Dual-Probe System Using Pyrenylmethyl-Modified Amino-Lna for Mismatch Detection

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