Sulfur Containing Acyclovir Derivatives: Synthesis, Cytotoxic Activity, and Cell Phenotype Studies

Abstract

New 2-amino-6-oxo-8-thioxo-9-substituted purine derivatives were prepared and assayed for the in vitro cytotoxic activity. Some products exhibited moderate activity on HT-1080 cells and rather high activity on MG-22A cells.

Keywords:

• Sulfur
• acyclovir
• antiherpetic drugs

Notes

^aTD₅₀-Concentration (mole/l × 10³) providing 50% cell killing effect [(CV+ MTT)/2]; NO Concentration (%).

^bNA-inactive.