2′-O-Dimethylaminoethoxyuridine and 5-Dimethylaminopropargyl Deoxyuridine for at Base Pair Recognition in Triple Helices

Lavinia Brennan School of Chemistry, University of Southampton, Highfield, Southampton, United Kingdom

Guomei Peng School of Chemistry, University of Southampton, Highfield, Southampton, United Kingdom

Natarajan Srinivasan School of Chemistry, University of Southampton, Highfield, Southampton, United Kingdom

Keith R. Fox School of Biological Sciences, Basset Crescent East, University of Southampton, Southampton, United Kingdom

Tom Brown School of Chemistry, University of Southampton, Highfield, Southampton, United Kingdom

Abstract

The nucleoside analogues 2′-O-dimethylaminoethoxy uridine and 5-dimethylaminopropargyl deoxyuridine have been synthesised and incorporated into oligonucleotides. Their triplex-stabilising properties have been determined in fluorescence melting experiments.

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This research was funded by grants from BBSRC and EU. Oligonucleotide synthesis was carried out by ATDBio Ltd. (www.atdbio.com).

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2′-O-Dimethylaminoethoxyuridine and 5-Dimethylaminopropargyl Deoxyuridine for at Base Pair Recognition in Triple Helices

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2′-O-Dimethylaminoethoxyuridine and 5-Dimethylaminopropargyl Deoxyuridine for at Base Pair Recognition in Triple Helices

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