Oligonucleotide Synthesis Using Ionic Liquids as Soluble Supports

Abstract

The continuing evolution of the methodology for the solution-phase synthesis of oligonucleotides using soluble ionic tags as handles for easy purification is described. This methodology may provide a more cost efficient route for the large scale synthesis of oligonucleotides.

Keywords:

• Oligonucleotides
• soluble ionic tags

We would like to thank the National Science and Engineering Council of Canada (NSERC) for funding of our research.

Notes

^aFrom impure product yield due to lack of observable product loss in purification media and lack of starting material in final product by MS.