2′,3′-Isopropylidene Group, A Molecular Scaffold to Study the Activity of Adenosine and Adenylate Deaminase on Adenosine Analogues Modified in the Ribose Moiety

Abstract

2 ′,3 ′-Isopropylidene group can be used as a molecular scaffold for the introduction of modifications at 5 ′ and 1 ′ positions of adenosine and these modified nucleosides are used to evaluate the biocatalytic activity of adenosine and adenylate deaminase.

Keywords:

• Nucleosides
• biocatalysis
• deamination
• adenosine deaminase
• adenylate deaminase

This work has been supported financially by Università degli Studi di Milano (Fondi FIRST).