New Developments of the “Lock-in” Modified cycloSal-d4TMPs

Dalibor Vukadinović-Tenter Department of Chemistry, Organic Chemistry, Faculty of Science, University of Hamburg, Hamburg, Germany

Jan Balzarini Rega-Institute for Medical Research, K. U. Leuven, Leuven, Belgium

Chris Meier Department of Chemistry, Organic Chemistry, Faculty of Science, University of Hamburg, Hamburg, Germany

Abstract

New developments of the “lock-in” modified cycloSal-d4TMP are reported. Novel prodrugs with variations in the linker chain were introduced. The synthesis, hydrolysis properties in different media (PBS, CEM/0- and liver extracts) and the antiviral activities against HIV are shown.

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New Developments of the “Lock-in” Modified cycloSal-d4TMPs

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New Developments of the “Lock-in” Modified cycloSal-d4TMPs

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