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Nucleosides, Nucleotides & Nucleic Acids Volume 26, 2007 - Issue 10-12
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Original Articles

A Pyrimidopyrimidoindole Nucleoside (dCPPI): Photophysical Properties and Thermal Stability of the Modified Dna Duplexes

Masahiro Mizuta CREST, JST (Japan Science and Technology Agency), Yokohama, Japan
,
Kohji Seio CREST, JST (Japan Science and Technology Agency), Yokohama, Japan; Frontier Collaborative Research Center, Tokyo Institute of Technology, Yokohama, Japan
,
Kenichi Miyata Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan
,
Akihiro Ohkubo CREST, JST (Japan Science and Technology Agency), Yokohama, Japan; Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan
,
Haruhiko Taguchi CREST, JST (Japan Science and Technology Agency), Yokohama, Japan; Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan
&
Mitsuo Sekine CREST, JST (Japan Science and Technology Agency), Yokohama, Japan; Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan
Pages 1335-1338 | Published online: 05 Dec 2007
 
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Abstract

A new fluorescent deoxycytidine analog, 10-(2-deoxy-β -D-ribofuranosyl)-pyrimido[4′,5′ :4,5]-pyrimido[1,6-a]indole-6,9(7H)-dione (dC PPI ) was synthesized. Its fluorescent properties were studied in detail. It was found that this fluorescent nucleoside dC PPI could be used as a fluorescent label for DNA probes with minimal disturbance of their overall structure.

This work was supported by Grant-in-Aid of CREST of JST (Japan Science and Technology) and the Ministry of Education, Science, Sports and Culture, Grant-in-aid for Scientific Research (A). This study was also supported by Industrial Technology Research Grant Program in 1905 from New Energy and Industrial Technology Development Organization (NEDO) of Japan.

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