Abstract
A number of functionalized polyaza crown ether building blocks have been incorporated into DNA-conjugates as catalytic Cu 2+ binding sites. The effect of the DNA-conjugate catalyst on the stereochemical outcome of a Cu 2+-catalyzed Diels-Alder reaction will be presented.
Funding of this work was provided by The Nucleic Acid Center (NAC).
Notes
a 10 mM sodium phosphate, 100 mM NaCl, 0.1 mM EDTA, adjusted to pH 7.0, concentration of 1 μM for each DNA strand.