Abstract
In search for new antiviral agents, we have been interested in 1′-C-fluoromethyl branched ribonucleosides. In this paper, we describe the synthesis of 1′-C-fluoromethyladenosine via electrophilic fluorination of exo-glycal.
We thank Dr. V. Bichko (Idenix, Cambridge-USA) and M. Luizi (Idenix, Ula-Italy) for antiviral assays.
Current address for Richard Storer, VASTox plc, Abingdon, UK.