Evaluating Coupling Procedures for Synthesis of Lna-Peptide Conjugates

Abstract

As initial studies of block coupling of peptides with C-terminal glycines, we have evaluated of coupling of glycine building blocks under various conditions to a preassembled solid support bound LNA-fragment. Potentially competing side reaction have been studied and we have worked out a procedure for trifluoroacetyl protection of peptides.

Keywords:

• Oligonucleotides
• peptides
• conjugates
• protection
• coupling