Improvement of the Synthesis of Sugar Phosphonates Using Microwave Irradiations

Abstract

Sugar and nucleoside phosphonates have been prepared using a microwave-assisted reaction. Results concerning optimization of the reaction for various substrates as well as comparison of thermal and microwave experimental conditions of the Michaelis-Arbuzov reaction is reported.

Keywords:

• Arbuzov reaction
• microwave-assisted reaction
• nucleoside
• sugar phosphonates

This work was supported by Association pour la Recherche contre le Cancer (ARC). F. G and J. B. are grateful to the CNRS & Région Languedoc-Roussillon, and La Ligue contre le Cancer, respectively, for doctoral fellowships.