Novel Selective Biocatalytic Deacylation Studies on Key Precursors for Bicyclonucleosides

Ashok K. Prasad Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi, India

Sunil K. Singh Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi, India

Neerja Kalra Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi, India; Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Odense M, Denmark

Nidhi Singhal Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi, India

Jesper Wengel Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Odense M, Denmark

Virinder S. Parmar Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi, India

Abstract

Immobilized Candida antarctica lipase and Thermomyces lanuginosus lipase catalyze the deacylation of precursors of LNA analogs, 4′-C-acyloxymethyl-2′,3′,5′-tri-O-acyl-β-L-threo-pentofuranosylthymine and 4-C-acyloxymethyl-3,5-di-O-acyl-1,2-O-(1-methylethylidene)-β-L-threo-pentofuranose, respectively in a highly selective and efficient manner.

Keywords:

We thank the Danish Natural Science Research Foundation and the Department of Biotechnology (DBT, New Delhi, India) for financial support to this work. S. K. S. and N. K. thank the Council of Scientific and Industrial Research (CSIR, New Delhi) for the award of J. R. F. and S. R. F.

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Novel Selective Biocatalytic Deacylation Studies on Key Precursors for Bicyclonucleosides

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Novel Selective Biocatalytic Deacylation Studies on Key Precursors for Bicyclonucleosides

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