Synthesis and Properties of Pyrrolidine-Based Negatively Charged Dna Mimics

Abstract

A set of novel chiral pyrrolidine-based nucleotide mimics, in which nucleobase, hydroxyl group and phosphonic acid residue were attached to different carbon atoms of the pyrrolidine ring, was synthesized. These monomers were used for the synthesis of the corresponding oligomers, and their physico-chemical properties were evaluated.

Keywords:

• DNA mimics
• pyrrolidine
• hybridization
• antisense reagents

The authors thank Russian Foundation of Basic Research for financial support.

Notes

^a Examination is currently in progress.