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Abstract
Several linear and branched DNA structures from 80–200 nm with a biotine molecule in the middle have been prepared. These structures have been decorated by addition of positively charged gold nanoparticles carrying 4-(dimethylamino)pyridine ligands. Streptavidin binds to the central biotine molecule introducing a 20 nm gap in the structure in which a biotinylated nanoparticle can be introduced. The simplest structure (80 nm, linear) is formed by 4 oligonucleotides. By changing some of these components changes on length, shape, and recognition system easily can be introduced.
Project financed by E.E.C.C., IST-1999-11974, BIOAND and STRP 014006 Nano3D and Spanish Ministry of Education BFU2005-23719-E, NAN2004-09415-C05-03 and BFU2004-02048.