Highly Effective Non-Explosive Activators Based on Saccharin for the Synthesis of Oligonucleotides and Phosphoramidites

Nanda D. Sinha Avecia Biotechnology, Inc. Milford, Massachusetts, USA

Patrick Foster Avecia Biotechnology, Inc. Milford, Massachusetts, USA

Satya N. Kuchimanchi Avecia Biotechnology, Inc. Milford, Massachusetts, USA

Greg Miranda Avecia Biotechnology, Inc. Milford, Massachusetts, USA

Saied Shaikh Avecia Biotechnology, Inc. Milford, Massachusetts, USA

Dennis Michaud Avecia Biotechnology, Inc. Milford, Massachusetts, USA

Abstract

A new class of non-explosive activators has been developed based on heterocyclic tertiary amine salts of saccharin. These salts have been found to be highly effective in the synthesis of oligonucleotides and nucleoside phosphoramidites.

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Highly Effective Non-Explosive Activators Based on Saccharin for the Synthesis of Oligonucleotides and Phosphoramidites

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Highly Effective Non-Explosive Activators Based on Saccharin for the Synthesis of Oligonucleotides and Phosphoramidites

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