Mineral Supported Facile Synthesis of Novel 4-Hydroxybenzoxazin-2-Thione N-Nucleosides

Abstract

One-pot montmorillonite K-10 clay-supported reactions of substituted/unsubstituted salicylaldehyde and ribosyl/deoxyribosyl thioureas expeditiously yielded novel N-nucleosides, 4-hydroxy-3,4-dihydro-3-(β-D-ribofuranosyl or β-D-2 ′-deoxyribofuranosyl)-2 ^″-benz[e]-1,3-oxazin-2-thione via cycloisomerization of aldehyde intermediate under solvent-free microwave irradiation conditions.

Keywords:

• One-pot
• substituted salicylaldehyde
• mineral-supported
• microwaves
• solvent-free
• benzoxazin-2-thione N-nucleosides