An Expeditious Synthesis of Benzoxazine-2-Thione c-Nucleosides Via Cu(OTf)₂-Mediated Dehydrazinative β-Glycosylation

Abstract

A novel expeditious synthetic protocol for 1,3-benzoxazine-2-thione C-nucleosides via Cu(OTf)₂-mediated dehydrazinative β-glycosylation of 4-hydrazino-2H-benz[e]-1,3-oxazine-2-thiones with unprotected D-ribose is reported.

Keywords:

• 1,3-Benzoxazine-2-thione C-nucleosides
• unprotected D-ribose
• non-nucleoside reverse transcriptase inhibitor (NNRTI)

We sincerely thank the Sophisticated Analytical Instrument Facility (SAIF), Punjab University, Chandigarh, for providing microanalyses and spectra.