Synthesis of a Novel, Optically Active Uridine Analog Containing a 1,4-Dioxane Sugar Moiety. Synthesis of the Corresponding Dinucleotide

Abstract

A new optically active uridine nucleoside analogue in which a substituted 1,4-dioxane ring functioned as the sugar analogue was prepared from L-tartaric acid. The nucleoside analogue was further converted into the corresponding protected dinucleotide.

Keywords:

• Uridine analogs
• 1,4-dioxane
• nucleoside analogs
• dinucleotide analogs
• optically active
• heterocycle

The authors wish to thank the Norwegian Research Council (NFR) for generous financial support.