An Efficient Deprotection of N-Trimethylsilylethoxymethyl (SEM) Groups From Dinucleosides and Dinucleotides

Abstract

A convenient and efficient method for deprotection of N-(trimethyl)silylethoxymethyl (SEM) groups from thymidine dinucleoside and dinucleotide has been achieved. The SEM groups were easily removed in excellent yields from protected nucleosides, dinucleosides, and dinucleotides.

Keywords:

• Dinucleosides
• spore photoproduct
• S-adenosylmethionine
• spore photoproduct lyase

Keywords:

• SAM
• S-adenosylmethionine
• SPL, spore photoproduct lyase
• SP, spore photoproduct
• TES, triethylsilyl
• TBDMS, tert-butyldimethylsilyl.

Acknowledgments

This work has been supported by the National Institutes of Health (GM67804 to J.B.B.).