How to Use the Computing Environment R to Analyze ATP-Induced Ribonucleotide Reductase R1 Hexamerization Data

Abstract

R is an object oriented free and open source statistical computing environment. The R package Combinatorially Complex Equilibrium Model Selection is being developed to meet the analysis challenges of ribonucleotide reductase (RNR). An example of its use is given here. This example involves ATP-induced R1 hexamerization dynamic light scattering data that suggests that R1 hexamers have two types of a-sites, one that binds ATP and another that does not (here, R1 is the large subunit of RNR).

KEYWORDS:

• R
• combinatorial complexity
• equilibrium model selection
• RNR

Acknowledgments

This work was supported by the National Cancer Institute grant K25 CA104791.