Biological Efficiency of AMP Deaminase Inhibitor: 3-[2-(3-CARBOXY-4-BROMO-5,6,7,8-Tetrahydronaphthyl)Ethyl]-3,6,7,8-Tetrahydroimidazo[4,5]-[1,3]Diazepin-8-OL

T. Borkowski Department of Biochemistry, Medical University of Gdansk, Gdansk, Poland

E. M. Slominska Department of Biochemistry, Medical University of Gdansk, Gdansk, Poland

C. Orlewska Department of Organic Chemistry, Medical University of Gdansk, Gdansk, Poland

A. H. Y. Yuen Heart Science Centre, Imperial College London, London, United Kingdom

S. Al-Ayoubi King Saud University College of Medicine, King Fahad Cardiac Center, Riyadh, Saudi Arabia

P. Siondalski Department of Cardiothoracic Surgery, Medical University Gdansk, Gdansk, Poland

M. H. Yacoub Heart Science Centre, Imperial College London, London, United Kingdom

R. T. Smolenski Department of Biochemistry, Medical University of Gdansk, Gdansk, Poland; Heart Science Centre, Imperial College London, London, United Kingdom

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Abstract

AMP deaminase could be a potential target for treatment of heart disease but experimental evaluation of this concept is difficult due to limited availability of inhibitors with proven efficiency in biological systems. This study evaluated the effect of 3-[2-(3-carboxy-4-bromo-5,6,7,8-tetrahydronaphthyl)ethyl]-3,6,7,8-tetrahydroimidazo [4,5-d][1,3]diazepin-8-ol, an AMP deaminase inhibitor (AMPDI) on the pathways of nucleotide metabolism in perfused rat heart. We show that AMPDI at 0.3 mM concentration effectively inhibits AMP deaminase in this experimental model.

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Acknowledgments

This study was supported by the Ministry of Science of Poland (N401 101 31/2201 and W-72) and the Magdi Yacoub Institute.

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Biological Efficiency of AMP Deaminase Inhibitor: 3-[2-(3-CARBOXY-4-BROMO-5,6,7,8-Tetrahydronaphthyl)Ethyl]-3,6,7,8-Tetrahydroimidazo[4,5]-[1,3]Diazepin-8-OL

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Biological Efficiency of AMP Deaminase Inhibitor: 3-[2-(3-CARBOXY-4-BROMO-5,6,7,8-Tetrahydronaphthyl)Ethyl]-3,6,7,8-Tetrahydroimidazo[4,5]-[1,3]Diazepin-8-OL

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