Synthesis of N-Aminopyrazinium Analogs of Cytidine and 2′-Deoxycytidine

Miroslav Bobek Department of Experimental Therapeutics, Roswell Park Cancer Institute, Buffalo, New York, 14263

Pittaya Tuntiwachwuttikul Department of Medicinal Chemistry, School of Pharmacy, State University of New York at Buffalo, Buffalo, New York, 14260

M. Mohsen Ismail Department of Medicinal Chemistry, School of Pharmacy, State University of New York at Buffalo, Buffalo, New York, 14260

Thomas J. Bardos Department of Experimental Therapeutics, Roswell Park Cancer Institute, Buffalo, New York, 14263

Abstract

N-Aminopyrazine analogues of cytidine and 2′-deoxycytidine were prepared from 1-(β-D-ribofuranosyl)-1,2-dihydro-2-oxopyrazine and 1-(2-deoxy-β-D-ribofuranosyl)-1,2-dihydro-2-oxopyrazine, respectively, by amination with O-mesitylenesulfonylhydroxylamine.

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Synthesis of N-Aminopyrazinium Analogs of Cytidine and 2′-Deoxycytidine

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Synthesis of N-Aminopyrazinium Analogs of Cytidine and 2′-Deoxycytidine

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