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Abstract
An indirect method for investigating evidence of the formation of full length deadenylated phosphorothioate oligonucleotide (ISIS 2105) as a degradation product is reported through synthesis of its deadenylated analog. Alternatively, use of Leumann's method for the synthesis of authentic deadenylated ISIS 2105 using the tert-butyldimethylsilyl protecting group at the anomeric hydroxyl function of the furanose ring failed in our hands.