Precursors for the Synthesis of Substituted 1,3,4-Thiadiazolf, C-Nucleosides, Analogues of Tiazofurin and Related Compounds

Abstract

The synthesis of 2-substituted 1,3,4-thiadiazole C-glycosides is described by building a heterocyclic system at the aldehyde end of a series of sugar derivatives. Acid catalyzed dehydration of the polyhydroxylic chain resulted in C-nucleoside, an analogue of tiazofurin.