Rare Earth Metal Ions for DNA Hydrolyses and Their Use to Artificial Nuclease¹

Makoto Komiyama Department of Industrial Chemistry, Faculty of Engineering, University of Tokyo, Hongo, Tokyo, 113, Japan

Naoya Takeda Department of Industrial Chemistry, Faculty of Engineering, University of Tokyo, Hongo, Tokyo, 113, Japan

Tetsuro Shiiba Institute of Materials Science, University of Tsukuba, Tsukuba, Ibaraki, 305, Japan

Yota Takahashi Department of Industrial Chemistry, Faculty of Engineering, University of Tokyo, Hongo, Tokyo, 113, Japan

Yoichi Matsumoto Institute of Materials Science, University of Tsukuba, Tsukuba, Ibaraki, 305, Japan

Morio Yashiro Department of Industrial Chemistry, Faculty of Engineering, University of Tokyo, Hongo, Tokyo, 113, Japan

Abstract

Phosphodiester linkages in linear DNAs are efficiently hydrolyzed by rare earth metal salts. The activities of CeCl3 and Ce(NH₄)₂(NO₃)₆ are especially large. Artificial hydrolytic nuclease for highly selective scission of DNA has been prepared by the attachment of Ce(IV) ion to a DNA oligomer as a sequence recognizing moiety.

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Rare Earth Metal Ions for DNA Hydrolyses and Their Use to Artificial Nuclease¹

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Rare Earth Metal Ions for DNA Hydrolyses and Their Use to Artificial Nuclease¹