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Abstract
New synthetic methods for pyrimidine ring-expanded xanthosine, guanosine, and inosine analogues containing imidazo [4, 5-e][1, 4] diazepine nucleus are described. Treatment of N 1 -substituted inosine derivatives 5, 12, 19 with aqueous NaOH gave 5-amino-4-(N-substituted carbamoyl)imidazole derivatives, followed by appropriate manipulations to cyclize these to constitute imidazo[4, 5-e][1, 4]diazepine nucleosides 11, 17, 22.