Hybridization of Alternating Cationic/Anionic Oligonucleotides to RNA Segments

Paul M. Jung Department of Chemistry, Northwestern University, Evanston, IL, 60208, U.S.A.

Gary Histand Department of Chemistry, Northwestern University, Evanston, IL, 60208, U.S.A.

Robert L. Letsinger Department of Chemistry, Northwestern University, Evanston, IL, 60208, U.S.A.

Abstract

It is shown that oligonucleotide analogues containing alternating phosphodiester groups and cationic groups linked to phosphorus through an amidate bond hybridize to complementary RNA segments. An improved synthetic procedure for the alternating compounds is also described.

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Hybridization of Alternating Cationic/Anionic Oligonucleotides to RNA Segments

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Hybridization of Alternating Cationic/Anionic Oligonucleotides to RNA Segments

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