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Nucleosides and Nucleotides Volume 14, 1995 - Issue 7
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Original Articles

Note: A Convenient Method for the Preparation of N2, N2-Dimethylguanosine

Anna Maria Aviñó Centro de Investigacion y Desarrollo. C.S.I.C., Jordi Girona 18-26, 08034, Barcelona, Spain
,
Adrian Mayordomo Centro de Investigacion y Desarrollo. C.S.I.C., Jordi Girona 18-26, 08034, Barcelona, Spain
,
Ruth Espuny Centro de Investigacion y Desarrollo. C.S.I.C., Jordi Girona 18-26, 08034, Barcelona, Spain
,
Montse Bach Centro de Investigacion y Desarrollo. C.S.I.C., Jordi Girona 18-26, 08034, Barcelona, Spain
&
Ramon Eritja European Molecular Biology Laboratory, Meyerhofstrasse 1, Postfach 10.2209., 69012, Heidelberg, Germany
Pages 1613-1617 | Received 05 Jan 1995, Accepted 21 Apr 1995, Published online: 24 Sep 2006
 
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Abstract

The preparation of N2, N2-dimethylguanosine is described. The use of the 2-(p-nitrophenyl)ethyl group instead of the benzyl protecting group for the O6 position of the guanine ring resulted in better yields and shorter protocols.

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